Its history dates back to the 16th century, when the canon of the Cathedral of Santiago, Juan Ibáñez de Mondragón, acquired the properties that would become the Pazo de Santa Cruz, known at the time as the Tower and the Casar de Ortigueira, and later his nephew the cardinal, -dignity of the cathedral of Santiago- Juan de Mondragón, extended the property. The church was built, the buildings were arranged and the skeleton of what is now the possession with olive and vine plantations was drawn. The fountains, the ponds, the waterfall, the house, the church, the horreo (granary) and the rest of the buildings are some of its attractions.
It was in the seventeenth century when Andrés Ibáñez de Modragón commissioned some works to be carried out on the pre-existing buildings. He hired the services of Domingo de Andrade for the design. During this period the monumental fountain designed by the architect Diego de Romay was also built.
In the 19th century the Corralón, the greenhouse was built and, above all, the collection of plants increased considerably. Subsequently, successive improvements and reforms have been produced that have given the pazo its current structure and appearance.